Non-Stimulant ADHD Medications Explained

When most people think of ADHD medication, they think of stimulants. But non-stimulant medications are a real, effective option for many adults. Here is what you should know.

Atomoxetine (Strattera)

• What it is: The first non-stimulant approved for ADHD. Approved for adults and children.
• How it works: It raises norepinephrine, a brain chemical tied to attention.
• Timing: Some people notice changes in 2 to 4 weeks. Full effect can take 6 to 8 weeks or longer.
• Common side effects: Upset stomach, lower appetite, tiredness, and dry mouth.

Viloxazine (Qelbree)

• What it is: A newer non-stimulant approved for adults in 2022.
• How it works: It also affects norepinephrine, along with some serotonin activity.
• Timing: Some people notice benefits within the first couple of weeks.
• Common side effects: Sleepiness, headache, and lower appetite.

• What it is: Originally a blood pressure medicine. The extended-release form is approved for ADHD in children and teens and is sometimes used for adults.
• How it works: It strengthens signals in the part of the brain that manages attention and impulse control.
• Helpful for: Emotional reactivity, impulsivity, and trouble sleeping.
• Common side effects: Sleepiness, dizziness, and lower blood pressure.

Extended-release clonidine (Kapvay)

• What it is: Similar to guanfacine.
• Helpful for: Hyperactivity, irritability, and sleep.
• Common side effects: Sleepiness and lower blood pressure. It should not be stopped suddenly.

Bupropion (Wellbutrin)

Bupropion is an antidepressant that some clinicians use off-label for ADHD, especially when depression is also present.

Benefits of non-stimulants

• Steady effect all day and evening
• No controlled substance refill rules
• Low risk of misuse
• Can be combined with other treatments

Things to keep in mind

• They take longer to work, so patience matters.
• Take them every day, even on weekends.
• Tell your clinician about every side effect. Small dose changes often help.

Non-stimulants at Anora

In every state where Anora is licensed, our psychiatric nurse practitioners can prescribe non-stimulant medications when clinically appropriate. That includes Arizona, Colorado, Connecticut, Delaware, Florida, Georgia, Idaho, Iowa, Kansas, Minnesota, Nebraska, New Hampshire, North Carolina, North Dakota, Vermont, Washington State, and Washington, DC.

The bottom line

Non-stimulants are not a backup plan. For many adults, they are the best fit. Talk with your clinician about which one matches your symptoms and goals.